varostreamIn this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
Episodes
XGBoost Model with CMR Features for Prognostic Assessment in Patients With ST‑Segment Elevation Myocardial Infarction | JACC: Asia
Commentary by Dr. Yoriyasu Suzuki.
4:35Design and Rationale of GPS-CAD: Global Pretest Probability Study of Coronary Artery Disease | JACC: Asia
Commentary by Dr. Junjie Yang.
4:16Prediction of Paroxysmal Atrial Fibrillation with Incorporating Genomic Information Into AI-Based ECG Analysis | JACC: Asia
Commentary by Dr. Qinkai Yu.
3:07October 2026 Summary | JACC: CardioOncology
Editor-in-Chief Dr. Bonnie Ky introduces the October 2026 issue of JACC: CardioOncology, featuring Part 1 of a special focus on immunology and cardio-oncology. This issue brings together state-of-the-art reviews, primers, original research, and clinical cases examining the immune system's central role in cancer and cardiovascular disease. Topics include the mechanisms and clinical implications of cancer immunotherapies and the immune system's contributions to the cardiovascular effects of cytotoxic chemotherapy, with implications for scientific discovery and patient care.
1:50Fibrotic Rewiring of CD8+ T-cells by Doxorubicin Drives Pathological Remodeling of Cardiac Extracellular Matrix | JACC: CardioOncology
Dr. Caitlin O'Meara discusses a JACC: CardioOncology study showing that doxorubicin reprograms CD8+ T cells into matrix-remodeling T cells (mxT-cells) that produce lysyl oxidase (LOX) and stiffen the cardiac extracellular matrix through HIF1α-P53-TGFβ signaling. She explains how this new immune mechanism of anthracycline cardiotoxicity could lead to therapies that prevent cardiac fibrosis, cardiomyopathy, and heart failure in patients treated with chemotherapy.
2:36High-Sensitivity Cardiac Troponin T and I Discordance in Patients Receiving Immune Checkpoint Inhibitors | JACC: CardioOncology
Dr. David Austin discusses a JACC: CardioOncology study showing that high-sensitivity cardiac troponin T was elevated in 37.9% of patients starting immune checkpoint inhibitor (ICI) therapy, compared with only 1.8% for high-sensitivity troponin I, a discordance linked to older age, male sex, and kidney dysfunction. He explains what this means for troponin assay selection, baseline testing, and ICI myocarditis surveillance, helping cardiologists and oncologists avoid unnecessary cancer treatment interruptions and immunosuppression.
5:03Inflammatory Cell Profiles in Early- and Late-Manifestation Immune Checkpoint Inhibitor Myocarditis | JACC: CardioOncology
Dr. Cristina Gil-Cruz discusses a JACC: CardioOncology study comparing early- and late-manifestation immune checkpoint inhibitor (ICI) myocarditis, where endomyocardial biopsies showed greater T-cell and macrophage infiltration in early cases despite similar left ventricular ejection fraction and fibrosis. She explains what these inflammatory cell profiles mean for cardio-oncology care, from immunosuppression and ICI rechallenge to balancing cardiac safety with effective cancer immunotherapy.
3:30Impact of Device Position and Aortic Valve Prolapse on Outcomes After Transcatheter VSD Closure | JACC: Asia
Commentary by Dr. Timothy Un.
3:33Prognostic Impact of Residual Thrombus After Aspiration Thrombectomy in ST-Elevation Myocardial Infarction | JACC: Asia
Commentary by Dr. Ziyad Ghazzal.
4:26Sex-Specific Lipid, Apolipoprotein B, and Lipoprotein(a) Responses to Berberine Based on 2 Randomized Placebo-Controlled Trials | JACC: Asia
Commentary by Dr. Yihang Fan.
3:22Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases | JACC: Asia
Commentary by Dr. Hongmei Yan.
3:58Efficacy and Safety of Quarterly Dosing SHR-1918 in Patients With Suboptimally Controlled Hyperlipidemia | JACC: Asia
Commentary by Dr. Xiaojie Xie.
4:31Oncologic Benefits and Cardiovascular Risks of Pembrolizumab: Insights From a Nationwide Lung Adenocarcinoma Cohort | JACC: Asia
Commentary by Dr. Koohyar Ahmadzadeh.
4:20Author Interview: Cholesterol Management Gaps Among Patients with Established Coronary Artery Disease Hospitalized for Acute Coronary Events | JACC: Advances
Dinesh Kalra, Todd Villines, and Lisandro Colantonio discuss the importance of this article, what encouraged Dr. Colantonio to conduct this research, and how clinicians can address the concerns patients have.
24:47Association of Implantation Depth with Hemodynamics and Mechanical Consequences in Small Valve-in-Valve TAVR | JACC: Asia
Commentary by Dr. Shinichi Shirai
4:00Comparison of ASCVD Risk Prediction Models in STEMI: Insights from a South Asian Cohort | JACC: Asia
Commentary by Dr. Justin Paul Gnanaraj
4:01Author Interview: Defining Clinically Meaningful Within-Patient Changes in Heart Failure | JACC: Heart Failure
Akshay Desai and Amin Yehya discuss the newest JACC: Heart Failure Position Statement that proposes a pragmatic framework for defining clinically meaningful within-patient changes across heart failure outcomes to improve the patient-centeredness of care during shared decision-making. Learn more about the article: https://www.jacc.org/doi/10.1016/j.jchf.2026.103310
25:48Deep Dive Dialogue: Effect of Evolocumab on Grafts Post-Coronary Artery Bypass Surgery: Post-hoc Analysis of NEWTON-CABG CardioLink-5 | JACC: Advances
Dinesh Kalra, Andrew Choi, and G. B. John Mancini discuss the author group's post hoc analysis of the randomized NEWTON-CABG CardioLink-5 trial.
23:52Issue Summary: September 2026 | JACC: Advances
Audio Summary of three articles from the September 2026 issue of JACC: Advances.
9:24Multimodality Imaging and Pace-Mapping Patterns in Patients With Cardiac Sarcoidosis and Ongoing Inflammation Undergoing Ventricular Tachycardia Ablation | JACC: Clinical Electrophysiology
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study of ventricular tachycardia ablation in patients with active cardiac sarcoidosis. Using integrated FDG-PET and cardiac MRI imaging, the investigators found that VT exit sites were often located in areas of active inflammation, while more proximal circuit sites were associated with scar. Patients in whom only VT exit sites could be identified had substantially higher VT recurrence rates, suggesting that targeting deeper portions of the VT circuit may improve outcomes.
5:11Author Interview: Aortic Stenosis Mortality Across the TAVR Expansion Era, 1999-2024: Rising Mortality in Middle-Aged Adults and a Widening Rural-Urban Gap | JACC: Advances
Nicole Bhave, Ashwini Kerkar, and Ahmed Kamal Siddiqi discuss what inspired this study, differences in mortality trends among age groups, and the most important takeaways from the paper.
23:09Computed Tomography–Defined Ridges and Functional Mapping in Ablation of Postinfarction Ventricular Tachycardia
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating how CT-defined myocardial ridges and functional mapping can be combined to identify critical ablation targets in post-infarction ventricular tachycardia. The investigators found that VT target sites frequently localized to CT-defined ridges, particularly those associated with primary deceleration zones, suggesting that functional mapping can help distinguish active arrhythmogenic ridges from inactive ones and support more targeted VT ablation.
4:42Hemodynamic Responses to Exercise and Predictors of Exercise Capacity in Mitral Stenosis: Exercise Catheterization Study | JACC Asia
Commentary by Dr. Jian'an Wang.
0:59Clopidogrel Vs Aspirin Monotherapy for Secondary Prevention After Percutaneous Coronary Intervention: A Nationwide Cohort Study | JACC Asia
Commentary by Dr. Jian'an Wang.
0:58Effect of Colchicine on Left Atrial Mechanics in Rheumatic Heart Disease: COL-RHD A Pilot Trial | JACC Asia
Commentary by Dr. Jian'an Wang.
0:56Long-Term Survival of Balloon Pulmonary Angioplasty for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Multicenter Study | JACC Asia
Commentary by Dr. Jian'an Wang.
1:00The Impact of PCSK9 Inhibitors on Circulatory Inflammation: Mechanisms, Evidence, and Application Prospects | JACC Asia
Commentary by Dr. Jian'an Wang.
0:51Cardiometabolic Multimorbidity and Sympathetic Overactivity: Translational Rationale for Combined Hepatic–Renal Denervation | JACC Asia
Commentary by Dr. Jian'an Wang.
0:57Predictive Value of Imaging-Based Classifications for Conservative Management Failure in Isolated Superior Mesenteric Artery Dissection | JACC Asia
Commentary by Dr. Jian'an Wang.
0:55The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications | JACC Asia
Commentary by Dr. Jian'an Wang.
1:11Vutrisiran in East Asian Patients With Transthyretin Amyloidosis With Cardiomyopathy: Post-Hoc Analysis of HELIOS-B | JACC Asia
Commentary by Dr. Jian'an Wang.
1:08Cost-Effectiveness of TAVI VS Minimally Invasive SAVR for Low-Risk Aortic Stenosis in Japan | JACC Asia
Commentary by Dr. Jian'an Wang.
0:54Novel Transcatheter Edge-to-Edge Repair System for High-Risk Primary Mitral Regurgitation: 2-Year Pivotal Trial Outcomes | JACC Asia
Commentary by Dr. Jian'an Wang.
0:55Patient Characteristics and Diagnosis of Transthyretin Amyloid Cardiomyopathy in Japan: Baseline Analysis of J-COSSA | JACC Asia
Commentary by Dr. Jian'an Wang.
0:59Understanding Outcomes in Hemodialysis Patients Who Underwent Transcatheter Aortic Valve Replacement With the Latest Devices | JACC Asia
Commentary by Dr. Jian'an Wang.
0:507-Year Outcomes of Balloon-Expandable Versus Self-Expanding Valves in Women Undergoing Transcatheter Aortic Valve Replacement | JACC Asia
Commentary by Dr. Jian'an Wang.
0:48Atrial Fibrillation and Clinical Outcomes Following Mitral Transcatheter Edge-To-Edge Repair According to Mitral Regurgitation Etiology | JACC Asia
Commentary by Dr. Jian'an Wang.
1:03Wearable Electrocardiogram Technologies for the Early Detection of Acute Coronary Syndromes
Commentary by Dr. Jian'an Wang.
1:02Association Between Current of Injury Magnitude and Intraoperative R-Wave Amplitude Fluctuation After Pacing Lead Implantation | JACC Asia
Commentary by Dr. Jian'an Wang.
0:52August 2026 Issue Summary
Audio Summary of the August 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
19:09July 2026 Issue Summary
Audio Summary of the July 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
9:51Author Interview: Who Will Care for the Heart? Structural Changes in the U.S. Cardiology Workforce, 2005-2023 | JACC: Advances
23:17Author Interview: Clinical Characteristics and Emergency Response to Sudden Cardiac Arrest/Death Secondary to Cardiomyopathies in Young Athletes | JACC: Advances
Matt Martinez and Bradley Petek discuss how the study came about, what results were discovered, and what call to action this study brings.
10:36Prognostic Value of Right Ventricular Circumferential Strain in Patients Undergoing Isolated Tricuspid Valve Surgery | JACC: Asia
Commentary by Dr. Kevin Ka-Ho Kam
4:55Radial Wall Strain for Predicting Severe Dissection After Drug-Coated Balloon | JACC: Asia
Commentary by Dr. Lei Song
3:52Issue Summary: August 2026 | JACC: Advances
Audio Summary of three articles from the August 2026 issue of JACC: Advances.
9:53Author Interview: Opportunistic Genetic Testing for Familial Hypercholesterolemia in Premature Acute Coronary Syndrome: Results of ACCURATE Study | JACC: Advances
Michael Wilkinson, Dinesh Kalra, Liam Brunham, and Robert Rosensen discuss the motivation behind the ACCURATE Study, unmet needs in identifying and treating HeFH, and how future studies can be designed to address the unmet need of identifying patients with HeFH and starting intensive LLT earlier in life.
18:42Author Interview: Social Drivers of Health Advisory: Cardiovascular Disease Projections Through 2050 | JACC: Advances
Dinesh Kalra and Khadijah Breathett discuss the estimated future projections of risk factors for CVD, individual CVD conditions (i.e. heart failure), and total CVD from 2020 to 2050 according to SDOH of the U.S. using the National Health and Nutrition Examination Survey, Medical Expenditure Panel Survey, and U.S. Census.
24:02Computed Tomography–Derived Abrupt Wall-Thickness Transitions as Complementary Markers of Ventricular Tachycardia Substrate in Ischemic Cardiomyopathy
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating whether abrupt wall-thickness transitions on cardiac CT scans can help identify critical ventricular tachycardia (VT) substrate in patients with ischemic cardiomyopathy. The investigators found that these CT-derived structural markers frequently co-localized with VT isthmus boundaries and deceleration zones identified during electrophysiology studies, suggesting they may complement traditional mapping techniques and help guide VT ablation, particularly when arrhythmias are difficult to map.
5:12Author Interview: INSIGHT Model: Explainable Artificial Intelligence for Real-World EHR-Based Screening of Transthyretin Amyloidosis Cardiomyopathy | JACC: Advances
Dinesh Kalra and Javed Butler discuss the development of an artificial intelligence screening tool to identify high-risk patients who should be considered for diagnostic testing for ATTR-cardiomyopathy (ATTR-CM) from an unselected heart failure (HF) population.
16:42